Generating Different Electromagnetic Field Waveforms to Stimulate Blood Vessel Growth (2022)

Different pulsed electromagnetic fields (PEMF) have been investigated as potential therapeutic tools for promoting tissue repair. We demonstrated that new blood vessel growth (angiogenesis) can be stimulated by exposing human umbilical vein endothelial cells to PEMFs. The prevailing Ion Cyclotron Resonance (ICR) Hypothesis claims that physiological activity of various ions implicated in cell signaling processes can be altered when the ratio of applied signal frequency to the magnetic field is equal to the ionic charge-to-mass ratio. A commercial waveform generator was employed to create various signals based upon the ICR Hypothesis. We propose developing novel PEMF “tuned” to initiating angiogenesis, with the aim of treating soft tissue wounds, including chronic skin ulcers. This technology builds upon Food and Drug Administration (FDA)-cleared PEMF devices, used to promote bone growth in recalcitrant fractures and suggests applications for use of novel waveform patterns to support soft tissue regeneration.